Structural Features and Antiviral Activity of Sulphated Fucans from the Brown Seaweed Cystoseira Indica
نویسندگان
چکیده
منابع مشابه
Structural features and antiviral activity of sulphated fucans from the brown seaweed Cystoseira indica.
Natural compounds offer interesting pharmacological perspectives for antiviral drug development. In this study, we have analysed sulphated-fucan-containing fractions isolated from the brown seaweed Cystoseira indica. The crude water extract (CiWE) and the main fraction (CiF3) obtained by anion exchange chromatography had potent antiviral activity against herpes simplex virus types 1 (HSV-1) and...
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Cystoseira tamariscifolia is a brown alga which represents an important natural biomass on the Moroccan Atlantic coast. Study of the acute toxicity of this species was carried out on Swiss albinos mice. The LD50 was determined through the Spearman-Karber method by injecting the aqueous algal extract to 36 mice organized in lots of 6 animals each for 6 concentrations and the experiments were con...
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BACKGROUND Many viruses display affinity for cell surface heparan sulfate proteoglycans with biological relevance in virus entry. This raises the possibility of the application of sulfated polysaccharides in antiviral therapy. METHODS In this study, we analysed polysaccharide fractions isolated from Sebdenia polydactyla. RESULTS The purified xylomannan sulfate and its further sulfated deriv...
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Total lipids from the Brazilian brown seaweed Sargassum vulgare were extracted with chloroform/methanol 2:1 and 1:2 (v/v) at room temperature. After performing Folch partition of the crude lipid extract, the lipids recovered from the Folch lower layer were fractionated on a silica gel column eluted with chloroform, acetone and methanol. The fraction eluted with methanol, presented a strong orci...
متن کاملStructure and antiviral activity of sulfated fucans from Stoechospermum marginatum.
A sulfated fucan containing fraction (SmWE) was isolated from water extract of the brown seaweed Stoechospermum marginatum collected from the Arabian Sea. Anion exchange chromatography of the crude fraction results in the production of a sulfated fucan (F3) having a molecular mass of 40 kDa and specific rotation [alpha]D(30) - 124 degrees (c 0.5, H2O). NMR spectroscopic studies and methylation ...
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ژورنال
عنوان ژورنال: Antiviral Chemistry and Chemotherapy
سال: 2007
ISSN: 2040-2066,2040-2066
DOI: 10.1177/095632020701800305